Revenue Per Employee is calculated by dividing your revenue, for the current period, by all your full time equivalent employees (which you entered when setting up the company and this number can be amended in the Advance tab of Settings). For clients that outsource, this will also include full time equivalent subcontractors.
The underlying calculations can be found by clicking on the tile and flipping it around to reveal the graphs and numbers in more detail.
If you select a finalised month (see red square above) that isn't the financial year end then the figures will be annualised for the current financial period.
The little coloured number (either red or green) at the base of the figure box, is the percentage points difference in the revenue growth between now and the previous financial year.